Vesicle-Associated Membrane Proteins/VAMP Isoforms Orchestrate Platelet Cargo Trafficking

Authors

Jessie Begley
Aleah Wagner
Cameron Gibson
Jack McFarland
Shayan Mohammadmoradi
Harry Chanzu
Sidney W. Whiteheart
Smita Joshi

Files

Description

Platelets are crucial to maintaining the vascular microenvironment. Upon vascular injury, they release cargo contents from their granules. These molecules, either made by platelets themselves or endocytosed from the blood, influence various processes like inflammation, immunity, and wound healing. Platelet granule release is mediated by Soluble N-ethylmaleimide Sensitive Factor Attachment Protein Receptors (SNAREs). To drive secretion, vesicle (v)-SNARE on granules and target (t)-SNARE on the plasma membrane form a SNARE complex that mediates fusion. Platelets contain Vesicle-Associated Membrane Protein (VAMP)-2, -3, -4, -5, -7, and -8.

Publication Date

4-17-2024

Disciplines

Higher Education | Scholarship of Teaching and Learning

Recommended Citation

Begley, Jessie; Wagner, Aleah; Gibson, Cameron; McFarland, Jack; Mohammadmoradi, Shayan; Chanzu, Harry; Whiteheart, Sidney W.; and Joshi, Smita, "Vesicle-Associated Membrane Proteins/VAMP Isoforms Orchestrate Platelet Cargo Trafficking" (2024). 2024 Celebration of Student Scholarship - Poster Presentations. 83.
https://scholarworks.moreheadstate.edu/celebration_posters_2024/83