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Horses suffering from inflammatory airway disease (IAD) and recurrent airway obstruction (RAO), develop lower airway inflammation, resulting in an obstruction of the bronchioles. This obstruction is associated with the following clinical signs: coughing, airway mucus accumulation, increased respiratory effort at rest and exercise intolerance. (Couetil et al., 2016)

IAD affects horses of all ages including young athletic horses. However, RAO mainly affects horses over 7 years of age. The common treatment for RAO includes corticosteroids, bronchodilators, and meticulously adjusting the environment to lower dust particles.

Allogenic Alpha-2 macroglobulin has shown to have anti-inflammatory properties when injected in joint and soft tissue. (Cuellar et al., 2016) The main objective of our study is to test the safety and efficacy of nebulized allogenic alpha-2 macroglobulin in horses to treat RAO.

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Higher Education | Scholarship of Teaching and Learning

Safety of Nebulization of Allogenic Alpha-2 Macroglobulin in Horses



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