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Questions are surrounding the accuracy of the reported levels of nicotine contained in e-liquids. Many of the studies show significant inconsistencies in the amount of nicotine reported on e-liquid products and the amount detected in the e-liquids. The current methods rely on preparing e-liquids for analysis by performing dilutions based on volume, but due to the viscosity of the liquids this preparation technique is prone to method errors. This project aims to compare the nicotine content in samples prepared by volume to those prepared by mass. This was done by first measuring the densities of several e-liquids. Those densities were used to convert the volume-based preparation into a mass-based preparation. Nicotine content in samples prepared by mass and volume was then measured by high-performance liquid chromatography (HPLC).

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Higher Education | Scholarship of Teaching and Learning

Comparison of Nicotine Quantification in E-liquids Using Volume-Based Sample Preparation versus Mass-Based Sample Preparation



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