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Deoxyribonucleic acid (DNA) codes for proteins using a unique order of four major nitrogenous bases adenine, thymine, cytosine, and guanine. In several biological applications, such as the determination of DNA stability, production of biologic based drugs, and even taxonomic reorganization of species, it becomes necessary to understand the relative amounts of each nucleotide in a DNA sample, regardless of their sequence. However, most assays used to determine base composition use expensive equipment, harsh chemicals, and advanced computer software. In addition, the determination of base composition is an important educational tool in undergraduate laboratories, but these limitations are infeasible for many institutions. Therefore, our research focus is to develop an easier, safer, and faster base composition assay.

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Colorimetric Redox Reactions to Determine Base Composition in Unknown Monomeric DNA Samples



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