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Electronic cigarettes are one of the most commonly used methods of nicotine delivery, especially among the adolescent population. Due to the lack of regulation in manufacturer labeling of refillable nicotine solutions (e-liquids), the actual concentration of nicotine and other additives is variable as compared to the reported values. Misreporting of nicotine content is a contributor in the development of nicotine dependency and potentially tobacco product dependency. The objective of this research is to develop reliable analytical methods to study the variations in nicotine levels in e-liquids, and to identify and quantify other potentially harmful additives in e-liquids. In this research we used gas chromatographymass spectrometry (GCMS) and nuclear magnetic resonance (NMR) spectroscopy for identification of compounds, and we used high-performance liquid chromatography (HPLC) and GCMS for quantification of compounds.

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Analytical Method Development for the Analysis of E-Liquids



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