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Apurinic/apyrimidinic (AP or abasic) sites are DNA lesions that result from the loss of a nucleobase by hydrolysis of the N-glycosyl bond. It is estimated that AP sites are the most frequent lesions in cells with about 10,000-50,000 times per day per cell under typical aerobic conditions . The formation of AP sites is caused by environmental and cancer therapeutic genotoxins such as alkylating agents, oxidizing agents, ionizing radiation, and ultraviolet radiation.
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Stephens, Isaiah O. and Thomas, Elizabeth M., "A New Colorimetric Assay of Apurinic/Apyrimidinic (Abasic) Sites of Deoxyribonucleic acid (DNA) Using Bicinchoninic Acid [" (2022). 2022 Celebration of Student Scholarship - Poster Presentations. 24.
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